The Mouse Anti Human Vimentin Antibody from MyBioSource.com is a Mouse Monoclonal antibody to VIM, and Vimentin. This antibody recognizes Human, Mouse, Rat, Bovine, Canine, Donkey, Feline, Goat, Guinea Pig, Hamster, Horse, Non-Human Primate, Porcine, Rabbit, Sheep, and Other Mammalian antigen. The Mouse Anti Human Vimentin Antibody has been validated for the following applications: ELISA, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Introduction: Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines